Chemical Mixture MSDS Report Processing Procedure
Date：2025-12-22 09:26:59 Classification
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MSDS is a comprehensive legal document provided by chemical manufacturers or distributors to their customers, as required by law, detailing the characteristics of their chemicals. This guide provides a complete overview of the MSDS reporting process for chemical mixtures.
I. Core Preparations Before Reporting (Requirements Specific to Mixtures)
1. Composition Information Review
A complete Bill of Materials (BOM) is required, including:
Chemical Name (IUPAC Nomenclature) and CAS Number
Mass Percentage Concentration (accurate to two decimal places)
SDS provided by the supplier (if the component is purchased)
2. Regulatory Standard Confirmation
Domestic: Must comply with GB/T 16483-2008 "Safety Data Sheet for Chemicals - Contents and Item Order"
Export: Must match the target country's GHS version (e.g., EU CLP Regulation, US OSHA-HCS 2012)
Special Note: When the mixture contains a carcinogenic component ≥0.1% or a reproductive toxicity component ≥0.3%, toxicological data must be separately labeled.
II. Reporting Process (5 Steps)
1. Choose a Reporting Method
| Method | Applicable Scenarios | Advantages
| Engage a Professional Agency | Complex composition (≥5 components), exported to multiple countries and regions | Mitigating regulatory risks, high report acceptance
| Self-prepared | Simple mixtures (≤3 known components) | Low cost, fast response
Document Submission Checklist
Basic Documents:
① Product Safety Data Sheet Application Form (must be stamped)
② Intended use of the mixture (e.g., industrial cleaning, laboratory reagent, etc.)
③ Simplified production process flow diagram (indicating possible byproducts)
Special Circumstances Supplementary:
If containing unknown components, a comparative description of similar products or a toxicological test report (e.g., acute oral toxicity LD50 data) is required.
Testing and Evaluation
Mandatory Test Items (according to GHS classification):
Physical Hazards: Flash point (closed cup method), explosion limits, oxidizing properties
Health Hazards: Skin irritation (rabbit test), inhalation toxicity (LC50)
Testing Cycle: Routine 5-7 working days, expedited 3 working days (additional 30% fee applies)
Data Source Priority:
Laboratory measured data > 2. Derivation of component SDS data > 3. Literature Databases (e.g., ECOTOX, HSDB)
Report Preparation and Review
16 Core Contents (in mandatory order according to GB/T 16483):
1. Chemical and Company Identification (including emergency contact number 400-XXX-XXXX)
2. Hazard Overview (GHS pictogram + warning words + hazard description)
3. Composition/Information on Ingredients (all ≥1% hazardous components must be listed)
4. First Aid Measures (divided into skin contact/inhalation/ingestion scenarios)
5. Fire Fighting Measures (applicable extinguishing agents and fire fighting precautions)
6. Spill Response (containment dikes/selection of absorbent materials)
7. Handling and Storage (storage temperature ≤30℃, keep away from oxidizers)
8. Exposure Controls/Personal Protection (Recommended PPE: nitrile gloves + goggles)
9. Material Physicochemical Properties (Density, Viscosity, pH Value, etc.)
10. Stability and Reactivity (Incompatible Substances: Strong Acids, Strong Oxidizing Agents)
11. Toxicological Data (Acute Toxicity Data and Exposure Limits)
12. Ecological Data (LC50 Toxicity to Aquatic Organisms)
13. Waste Disposal (Incineration recommended, temperature ≥800℃)
14. Transport Information (UN Number, Packing Category, Marine Pollution Category)
15. Regulatory Information (Inclusion in the 2025 Edition of the China Hazardous Chemicals Catalogue)
16. Other Information (Date of Compilation, Version Number V1.0)
Report Delivery and Updates
Delivery Format: PDF electronic file (must be stamped with the official seal of the compiling unit) + Paper Report (Optional)
Validity: 5 years, but must be updated immediately in the following situations:
Component Change (Concentration change ≥ 5%)
Implementation of New Regulations (e.g., GHS 9th Revision comes into effect)
Update of Toxicological Data (Discovery of New Hazardous Properties)
III. Special Notes for Mixture Handling
Hazard Classification Rules
If the concentration of a component in a mixture exceeds the critical value, it must be classified according to GHS 7.1.3.2:
Example: A mixture containing 15% methanol (Flammable Liquid Category 2) → Classified as Flammable Liquid Category 3
(Because the methanol concentration is > 10%, the hazard level needs to be calculated according to the formula)
Data Gap Handling
When component toxicological data is unavailable, the following methods can be used:
QSAR (Quantitative Structural Relationship) model prediction
Extrapolation using analogues (analogical basis required)
Submit a "Data Gap Declaration" (only for non-hazardous chemicals)
Common Errors
❌ Omission of Trace Hazardous Components (e.g., 0.05% carcinogenic impurity content not labeled)
❌ Transport information conflicts with IMDG codes (e.g., UN3269 incorrectly classified as UN1993)
❌ First aid measures are not specific (failed to specify "rinse with plenty of running water for at least 15 minutes")
IV. Cost and Institution Selection
Cost Reference:
| Mixture Complexity | Basic Cost (RMB)
| Simple (≤3 components) | 500
Recommended Institution Qualifications:
Possesses CNAS accreditation (can be verified on the CNAS website)
Has experience in preparing mixtures (provides case studies of similar products within the past 3 years)
Supports multiple languages (English, Japanese, Spanish, etc.)
Shen Gongwang Security: 44030602006947